He bases his bottom line on a nationwide assessment of medical earnings and expenditures losses connected with arthritis in 2003, compared with statistics six years before. The findings and their implications are presented in the May issue of Arthritis & Rheumatism. The statement was motivated by developing issues about the collective and specific financial burden of arthritis, fueled by rising medical costs, from joint substitute surgery to biologic brokers, and the ranks of maturing Baby Boomers.The analysis showed that long-term methamphetamine use changes endogenous proteins in drug users, leading to aberrant immune responses. As a result, increased degrees of proinflammatory cytokines-proteins involved with immune response-may be considered a previously unrecognized molecular mechanism for the development of cardiovascular disorders such as vasculitus, an inflammation of the arteries. Our previous studies demonstrated that methamphetamine can glycate or add sugars to proteins, said Scripps Analysis Professor Kim Janda, who conducted this scholarly research in collaboration with Scripps Research Assistant Professor Tobin Dickerson and other colleagues.